The world was stunned in June 2016 when citizens in the United Kingdom voted for Britain to leave the European Union. On top of challenges posed by massive migration, terrorism and continuing economic difficulties, this was a severe blow to the European Union’s plans to achieve major gains for the people and nations of Europe by 2020. This outcome poses significant questions about the future of the European Union, but also the United Kingdom. Perhaps ironically, while the decision puts reform at the top of the EU agenda, it puts at risk the very existence of the United Kingdom. It also has major implications for other nations, as the EU leaders continue to seek a major role in external affairs, and to develop stronger relationships with countries in other parts of the world, not least Australia and New Zealand. At the same time, some British leaders have aspirations to recreate a dominant role for the ‘Anglosphere’. What might all of this mean for our region?